Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune

@inproceedings{Sun2016NovelSM,
  title={Novel small molecule 11β-HSD1 inhibitor from the endophytic fungus Penicillium commune},
  author={Weiguang Sun and Xintao Chen and Qingyi Tong and Hucheng Zhu and Yan He and Liang Lei and Yongbo Xue and Guangming Yao and Zengwei Luo and Jianping Wang and Hua Li and Yonghui Zhang},
  booktitle={Scientific reports},
  year={2016}
}
Two new phenone derivatives penicophenones A (1) and B (2), a new cyclic tetrapeptide penicopeptide A (3), and five known compounds were isolated from the culture broth of Penicillium commune, an endophytic fungus derived from Vitis vinifera. Compounds 1-3 were elucidated by extensive spectroscopic analyses including 1D and 2D NMR and HRESIMS. The absolute configurations of 1 and 3 were determined by comparing its ECD with related molecules and modified Marfey's analysis, respectively… CONTINUE READING