Novel small deletions of the p53 gene in late-stage B-cell chronic lymphocytic leukaemia.

@article{Gandini1994NovelSD,
  title={Novel small deletions of the p53 gene in late-stage B-cell chronic lymphocytic leukaemia.},
  author={Domenica Gandini and Gianluca Aguiari and Antonio Cuneo and Roberto Piva and Gian Luigi Castoldi and Laura del Senno},
  journal={British journal of haematology},
  year={1994},
  volume={88 4},
  pages={
          881-5
        }
}
A group of 20 CLL patients selected for advanced clinical stage p53 mutations were analysed by single-strand conformational polymorphism (SSCP) following PCR amplification of exons 5-9. In two patients abnormal SSCP of either exon 5 or exon 8 was found and PCR products were analysed by direct sequencing. A hemizygous or homozygous 12bp deletion at codon 135 and 3bp heterozygous deletion at codon 264 were detected; also, in the latter sample a heterozygous mutation at codon 282 (Arg to Gln) was… CONTINUE READING
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