Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation.

@article{Mirsky2008NovelSC,
  title={Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation.},
  author={Rhona Mirsky and Ashwin Woodhoo and David B Parkinson and Peter J. Arthur-Farraj and Ambily Bhaskaran and Kristj{\'a}n R. Jessen},
  journal={Journal of the peripheral nervous system : JPNS},
  year={2008},
  volume={13 2},
  pages={122-35}
}
Immature Schwann cells found in perinatal rodent nerves are generated from Schwann cell precursors (SCPs) that originate from the neural crest. Immature Schwann cells generate the myelinating and non-myelinating Schwann cells of adult nerves. When axons degenerate following injury, Schwann cells demyelinate, proliferate and dedifferentiate to assume a molecular phenotype similar to that of immature cells, a process essential for successful nerve regeneration. Increasing evidence indicates that… CONTINUE READING

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