Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways.

@article{Carvalho2003NovelST,
  title={Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways.},
  author={Carla Roberta de Oliveira Carvalho and Jos{\'e} Barreto Campello Carvalheira and Maria Helena Melo Lima and Suzana F Zimmerman and Luciana Chagas Caperuto and Ang{\'e}lica M. Amanso and Alessandra Lia Gasparetti and Vainer Meneghetti and Leonardo Ferreira Zimmerman and Licio A Velloso and M{\'a}rio Jos{\'e} Abdalla Saad},
  journal={Endocrinology},
  year={2003},
  volume={144 2},
  pages={638-47}
}
The actions of LH are mediated through a single class of cell surface LH/human chorionic gonadotropin receptor, which is a member of the G protein-coupled receptor family. In the present study we showed that LH induced rapid tyrosine phosphorylation and activation of the Janus kinase 2 (JAK2) in rat ovary. Upon JAK2 activation, tyrosine phosphorylation of signal transducer and activator of transcription-1 (STAT-1), STAT-5b, insulin receptor substrate-1 (IRS-1), and Src homology and collagen… CONTINUE READING

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Annales d'endocrinologie • 1989
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