Novel series of non-glycerol-based cationic transfection lipids for use in liposomal gene delivery.

@article{Banerjee1999NovelSO,
  title={Novel series of non-glycerol-based cationic transfection lipids for use in liposomal gene delivery.},
  author={Rahul Banerjee and Pratap Kumar Das and G V Srilakshmi and Arabinda Chaudhuri and Nalam Madhusudhana Rao},
  journal={Journal of medicinal chemistry},
  year={1999},
  volume={42 21},
  pages={4292-9}
}
A novel series of nontoxic and non-glycerol-based simple monocationic transfection lipids containing one or two hydroxyethyl groups directly linked to the positively charged nitrogen atom were synthesized. The in vitro transfection efficiencies of these new liposomal gene delivery reagents were better than that of lipofectamine, a widely used transfection agent in cationic lipid-mediated gene transfer. The most efficient transfection formulation was observed to be a 1:1:0.3 mol ratio of DHDEAB… CONTINUE READING