Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

@article{Jones2008NovelSA,
  title={Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.},
  author={Carrie K Jones and Ashley E. Brady and Albert Augustus Davis and Zixiu Xiang and Michael Bubser and Mohammed Noor Tantawy and Alexander S. Kane and Thomas M. Bridges and J. Phillip Kennedy and Stefania Risso Bradley and Todd E. Peterson and M. Sib Ansari and Ronald M. Baldwin and Robert M. Kessler and Ariel Y. Deutch and James J Lah and Allan I. Levey and Craig W Linsdley and Peter Jeffrey Conn},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 41},
  pages={
          10422-33
        }
}
Recent studies suggest that subtype-selective activators of M(1)/M(4) muscarinic acetylcholine receptors (mAChRs) may offer a novel approach for the treatment of psychotic symptoms associated with schizophrenia and Alzheimer's disease. Previously developed muscarinic agonists have provided clinical data in support of this hypothesis, but failed in clinical development because of a lack of true subtype specificity and adverse effects associated with activation of other mAChR subtypes. We now… CONTINUE READING
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