Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor.

@article{Joo2015NovelRO,
  title={Novel roles of ginsenoside Rg3 in apoptosis through downregulation of epidermal growth factor receptor.},
  author={Eun Ji Joo and Jaemoo Chun and Young Wan Ha and Hye Jin Ko and Mei-Ying Xu and Yeong Shik Kim},
  journal={Chemico-biological interactions},
  year={2015},
  volume={233},
  pages={25-34}
}
Ginsenoside Rg3 (Rg3), a pharmacologically active compound from red ginseng, has been reported to induce cell death in various cancer cell lines, although the specific mechanisms have not been well established. In the present study, Rg3 treatment to A549 human lung adenocarcinoma led to cell death via not only apoptotic pathways but also the downregulation of epidermal growth factor receptor (EGFR). We used cross-linker and cell enzyme-linked immunosorbent assays to show that Rg3 inhibited EGFR… CONTINUE READING