Novel roles of cAMP/cGMP‐dependent signaling in platelets

@article{Smolenski2012NovelRO,
  title={Novel roles of cAMP/cGMP‐dependent signaling in platelets},
  author={A. Smolenski},
  journal={Journal of Thrombosis and Haemostasis},
  year={2012},
  volume={10}
}
  • A. Smolenski
  • Published 2012
  • Chemistry, Medicine
  • Journal of Thrombosis and Haemostasis
Summary.  Endothelial prostacyclin and nitric oxide potently inhibit platelet functions. Prostacyclin and nitric oxide actions are mediated by platelet adenylyl and guanylyl cyclases, which synthesize cyclic AMP (cAMP) and cyclic GMP (cGMP), respectively. Cyclic nucleotides stimulate cAMP‐dependent protein kinase (protein kinase A [PKA]I and PKAII) and cGMP‐dependent protein kinase (protein kinase G [PKG]I) to phosphorylate a broad panel of substrate proteins. Substrate phosphorylation results… Expand
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