Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy.

@article{Chen2008NovelRF,
  title={Novel roles for protein kinase Cdelta-dependent signaling pathways in acute hypoxic stress-induced autophagy.},
  author={Jo-Lin Chen and Her Helen Lin and K. Kim and Anning Lin and Henry J Forman and David Kong Ann},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 49},
  pages={
          34432-44
        }
}
Macroautophagy, a tightly orchestrated intracellular process for bulk degradation of cytoplasmic proteins or organelles, is believed to be essential for cell survival or death in response to stress conditions. Recent observations indicate that autophagy is an adaptive response in cells subjected to prolonged hypoxia. However, the signaling mechanisms that activate autophagy under acute hypoxic stress are not clearly understood. In this study, we show that acute hypoxic stress by treatment with… CONTINUE READING
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