Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier.

  title={Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier.},
  author={Juan Kong and Zhongyi Zhang and Mark W Musch and Gang Ning and Jun Sun and John Hart and Marc Bissonnette and Yan Chun Li},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={294 1},
  • J. Kong, Zhongyi Zhang, Y. Li
  • Published 2008
  • Medicine, Biology
  • American journal of physiology. Gastrointestinal and liver physiology
Emerging evidence supports a pathological link between vitamin D deficiency and the risk of inflammatory bowel disease (IBD). To explore the mechanism we used the dextran sulfate sodium (DSS)-induced colitis model to investigate the role of the vitamin D receptor (VDR) in mucosal barrier homeostasis. While VDR(+/+) mice were mostly resistant to 2.5% DSS, VDR(-/-) mice developed severe diarrhea, rectal bleeding, and marked body weight loss, leading to death in 2 wk. Histological examination… 

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