Novel role of nucleostemin in the maintenance of nucleolar architecture and integrity of small nucleolar ribonucleoproteins and the telomerase complex.

@article{Romanova2009NovelRO,
  title={Novel role of nucleostemin in the maintenance of nucleolar architecture and integrity of small nucleolar ribonucleoproteins and the telomerase complex.},
  author={Liudmila G Romanova and Steven Kellner and Nobuko Katoku-Kikyo and Nobuaki Kikyo},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 39},
  pages={26685-94}
}
Nucleostemin (NS) is a nucleolar protein involved in the regulation of cell proliferation. Both overexpression and knockdown of NS increase the activity of the tumor suppressor protein p53, resulting in cell cycle arrest. In addition, NS regulates processing of pre-rRNA and consequently the level of total protein synthesis. Here, we describe a previously uncharacterized function of NS in the maintenance of the tripartite nucleolar structure as well as the integrity of small nucleolar… CONTINUE READING