Novel role of lactosylceramide in vascular endothelial growth factor-mediated angiogenesis in human endothelial cells.

@article{Rajesh2005NovelRO,
  title={Novel role of lactosylceramide in vascular endothelial growth factor-mediated angiogenesis in human endothelial cells.},
  author={Mohanraj Rajesh and Antonina Kolmakova and Subroto B Chatterjee},
  journal={Circulation research},
  year={2005},
  volume={97 8},
  pages={
          796-804
        }
}
Vascular endothelial growth factor (VEGF) has been implicated in angiogenesis associated with coronary heart disease, vascular complications in diabetes, inflammatory vascular diseases, and tumor metastasis. The mechanism of VEGF-driven angiogenesis involving glycosphingolipids such as lactosylceramide (LacCer), however, is not known. To demonstrate the involvement of LacCer in VEGF-induced angiogenesis, we used small interfering RNA (siRNA)-mediated silencing of LacCer synthase expression… CONTINUE READING

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