Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer.

Abstract

Gastric ulcer is a multifaceted process including acid secretion, reactive oxygen species generation, prostaglandin inhibition, and extracellular matrix (ECM) degradation. Matrix metalloproteinases (MMPs) have the ability to cleave and remodel the ECM. We investigated the activity and expression of MMP-9 and -2 in ethanol-induced acute gastric ulceration in… (More)

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Cite this paper

@article{Singh2007NovelRO, title={Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer.}, author={Laishram Pradeepkumar Singh and Parag Kundu and Krishnendu Ganguly and Amartya Mishra and Snehasikta Swarnakar}, journal={Free radical biology & medicine}, year={2007}, volume={43 2}, pages={289-99} }