Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease.

@article{Chi2011NovelRO,
  title={Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease.},
  author={Ying Chi and Yi Hua Fan and Lei He and Wei Liu and Xiaoyun Wen and Sha Zhou and Xuefeng Wang and Cui Zhang and Hui Kong and Laura Sonoda and Prem Tripathi and Carrie Jiaxin Li and Michelle S. Yu and Chuan Su and Gang Hu},
  journal={Aging cell},
  year={2011},
  volume={10 3},
  pages={368-82}
}
Aquaporin-4 (AQP4) is highly expressed in mammalian brains and is involved in the pathophysiology of cerebral disorders, including stroke, tumors, infections, hydrocephalus, epilepsy, and traumatic brain injury. We found that AQP4-deficient mice were hypersensitive to stimulations such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or lipopolysaccharide compared to wild-type (WT) littermates. In a mouse model of MPTP-induced Parkinson's disease (PD), AQP4-deficient animals show more… CONTINUE READING

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