Novel role of Wag31 in protection of mycobacteria under oxidative stress.

@article{Mukherjee2009NovelRO,
  title={Novel role of Wag31 in protection of mycobacteria under oxidative stress.},
  author={Partha Mukherjee and Kamakshi Sureka and Pratik Datta and Tofajjen Hossain and Subhasis Barik and Kali Pada Das and Manikuntala Kundu and Joyoti Basu},
  journal={Molecular microbiology},
  year={2009},
  volume={73 1},
  pages={103-19}
}
Wag31 of Mycobacterium tuberculosis belongs to the DivIVA family of proteins known to regulate cell morphology in Gram-positive bacteria. Here we demonstrate an unrecognized, novel role of Wag31 in oxidatively stressed mycobacteria. We report the cleavage of penicillin-binding protein 3 (PBP3) by the intramembrane metalloprotease Rv2869c (MSMEG_2579) in oxidatively stressed cells. Amino acids (102)A and (103)A of PBP3 are required for Rv2869c-mediated cleavage. Wag31(MTB), by virtue of its… CONTINUE READING