Novel role for the Lu/BCAM-spectrin interaction in actin cytoskeleton reorganization.

  title={Novel role for the Lu/BCAM-spectrin interaction in actin cytoskeleton reorganization.},
  author={Emmanuel Collec and M H Lecomte and Wassim El Nemer and Yves Colin and Caroline le van Kim},
  journal={The Biochemical journal},
  volume={436 3},
Lu/BCAM (Lutheran/basal cell-adhesion molecule) is a laminin 511/521 receptor expressed in erythroid and endothelial cells, and in epithelial tissues. The RK573-574 (Arg573-Lys574) motif of the Lu/BCAM cytoplasmic domain interacts with αI-spectrin, the main component of the membrane skeleton in red blood cells. In the present paper we report that Lu/BCAM binds to the non-erythroid αII-spectrin via the RK573-574 motif. Alanine substitution of this motif abolished the Lu/BCAM-spectrin interaction… CONTINUE READING


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Role of the interaction between Lu/BCAM and the spectrin-based membrane skeleton in the increased adhesion of hereditary spherocytosis red cells to laminin

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Organization of the human LU gene and molecular basis of the Lu ( a ) / Lu ( b ) blood group polymorphism

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