Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells


OBJECTIVES Polycystin-1 (PC1), a signalling receptor regulating Ca(2+)-permeable cation channels, is mutated in autosomal dominant polycystic kidney disease, which is typically characterized by increased cell proliferation. However, the precise mechanisms by which PC1 functions on Ca(2+) homeostasis, signalling and cell proliferation remain unclear. Here… (More)
DOI: 10.1111/j.1365-2184.2008.00529.x


9 Figures and Tables