Novel role for p90 ribosomal S6 kinase in the regulation of cardiac myofilament phosphorylation.


In myocardium, the 90-kDa ribosomal S6 kinase (RSK) is activated by diverse stimuli and regulates the sarcolemmal Na(+)/H(+) exchanger through direct phosphorylation. Only limited information is available on other cardiac RSK substrates and functions. We evaluated cardiac myosin-binding protein C (cMyBP-C), a sarcomeric regulatory phosphoprotein, as a… (More)
DOI: 10.1074/jbc.M110.202713


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