Novel role for insulin as an autocrine growth factor for malignant brain tumour cells.

@article{Arcaro2007NovelRF,
  title={Novel role for insulin as an autocrine growth factor for malignant brain tumour cells.},
  author={Alexandre Arcaro and Kathrin T. Doepfner and Danielle Boller and Ana Santos Guerreiro and Tarek Al Shalaby and Shaun P Jackson and Simone M Schoenwaelder and Olivier Delattre and Michael Andreas Grotzer and Barbara E. Fischer},
  journal={The Biochemical journal},
  year={2007},
  volume={406 1},
  pages={57-66}
}
AT/RTs (atypical teratoid/rhabdoid tumours) of the CNS (central nervous system) are childhood malignancies associated with poor survival rates due to resistance to conventional treatments such as chemotherapy. We characterized a panel of human AT/RT and MRT (malignant rhabdoid tumour) cell lines for expression of RTKs (receptor tyrosine kinases) and their involvement in tumour growth and survival. When compared with normal brain tissue, AT/RT cell lines overexpressed the IR (insulin receptor… CONTINUE READING

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