Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells.

  title={Novel role for STAT3 in transcriptional regulation of NK immune cell targeting receptor MICA on cancer cells.},
  author={Romain Bedel and Antoine Thiery-Vuillemin and Camille Grandcl{\'e}ment and J{\'e}r{\'e}my Balland and Jean-Paul R{\'e}my-Martin and Bernadette Kantelip and Jean-Ren{\'e} Pallandre and Xavier Pivot and Christophe Ferrand and Pierre Tiberghien and Christophe Borg},
  journal={Cancer research},
  volume={71 5},
The role of natural killer group 2, member D receptor (NKG2D)-expressing natural killer (NK) cells in tumor immunosurveillance is now well established. Nevertheless, tumor progression occurs despite tumor immunosurveillance, leading to cancer persistence in immunocompetent hosts. STAT3 plays a pivotal role both in oncogenic functions and in immunosuppression. In this study, we investigated the role of STAT3 in suppressing NK cell-mediated immunosurveillance. Using a colorectal cancer cell line… CONTINUE READING


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