Novel robust hepatitis C virus mouse efficacy model.

  title={Novel robust hepatitis C virus mouse efficacy model.},
  author={Qing Zhu and Yoko Oei and Dirk B. Mendel and Evelyn N. Garrett and Montesa B. Patawaran and Paul W. Hollenbach and Sharon Lea Aukerman and Amy J. Weiner},
  journal={Antimicrobial agents and chemotherapy},
  volume={50 10},
The lack of a robust small-animal model for hepatitis C virus (HCV) has hindered the discovery and development of novel drug treatments for HCV infections. We developed a reproducible and easily accessible xenograft mouse efficacy model in which HCV RNA replication is accurately monitored in vivo by real-time, noninvasive whole-body imaging of gamma-irradiated SCID mice implanted with a mouse-adapted luciferase replicon-containing Huh-7 cell line (T7-11). The model was validated by… CONTINUE READING
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