Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium.

@article{Bjrkman1999NovelRM,
  title={Novel ribosomal mutations affecting translational accuracy, antibiotic resistance and virulence of Salmonella typhimurium.},
  author={J Bj{\"o}rkman and Patrik Samuelsson and Dan I Andersson and David C Hughes},
  journal={Molecular microbiology},
  year={1999},
  volume={31 1},
  pages={
          53-8
        }
}
Many mutations in rpsL cause resistance to, or dependence on, streptomycin and are restrictive (hyperaccurate) in translation. Dependence on streptomycin and hyperaccuracy can each be reversed phenotypically by mutations in either rpsD or rpsE. Such compensatory mutations have been shown to have a ram phenotype (ribosomal ambiguity), increasing the level of translational errors. We have shown recently that restrictive rpsL alleles are also associated with a loss of virulence in Salmonella… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 61 CITATIONS, ESTIMATED 73% COVERAGE

Interactions of release factor RF3 with the translation machinery

  • Molecular Genetics and Genomics
  • 2015
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Bacterial adaption to novel selection pressures

VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

1999
2019

CITATION STATISTICS

  • 7 Highly Influenced Citations