Novel rhodanine derivatives induce growth inhibition followed by apoptosis.

@article{Moorthy2010NovelRD,
  title={Novel rhodanine derivatives induce growth inhibition followed by apoptosis.},
  author={Balaji T. Moorthy and Subban Ravi and Mrinal Ranjan Srivastava and Kishore Kumar Chiruvella and H Hemlal and Omana Joy and Sathees C. Raghavan},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 21},
  pages={6297-301}
}
We have designed and synthesized three novel compounds, 5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4-oxazolidinedione (ITO-1), and 5-benzilidene-3-ethyl rhodanine (BTR-1), and have tested their chemotherapeutic properties. Our results showed that all three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when… CONTINUE READING

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