Novel research horizons for presenilins and γ-secretases in cell biology and disease.

@article{Strooper2010NovelRH,
  title={Novel research horizons for presenilins and γ-secretases in cell biology and disease.},
  author={Bart De Strooper and Wim Annaert},
  journal={Annual review of cell and developmental biology},
  year={2010},
  volume={26},
  pages={235-60}
}
Presenilins are the catalytic subunits of larger tetrameric γ-secretase complexes. The degradome of these aspartyl proteases consists of at least 60 different substrates. γ-Secretase is key to regulated intramembrane proteolysis, releasing protein fragments that potentially transduce signals at both sides of the cell membrane. Characteristic for this novel form of cellular signaling is its irreversible nature, providing direction to biological processes. We discuss recent insights in structure… CONTINUE READING