Novel regulators in hematopoietic stem cells can be revealed by a functional approach under leukemic condition

@article{Cheng2016NovelRI,
  title={Novel regulators in hematopoietic stem cells can be revealed by a functional approach under leukemic condition},
  author={Hongyan Cheng and Yuejun Liu and Qiuli Jia and Shihui Ma and Weiping Yuan and Hairong Jia and Tao Cheng},
  journal={Leukemia},
  year={2016},
  volume={30},
  pages={2074-2077}
}
Defining novel functional regulators of hematopoietic stem cells (HSCs) is an important task in HSC biology as well as leukemia biology. To identify functional genes in HSCs, previous studies have used several strategies, such as microarrays, RNA-sequencing and complimentary DNA or short hairpin RNA screens. However, these studies were undertaken with the cells in homeostasis (steady state) in which many functional genes would be potentially masked. Here, we employed an unconventional approach… CONTINUE READING

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