Novel regulation of insulin secretion: the role of mitochondria.

  title={Novel regulation of insulin secretion: the role of mitochondria.},
  author={Pierre Maechler},
  journal={Current opinion in investigational drugs},
  volume={4 10},
Coupling of glucose entry to insulin secretion in pancreatic beta-cells depends on numerous intracellular metabolic steps. In this process, mitochondria play a central role, and defects in this organelle are associated with impaired glucose-evoked insulin release. In response to a glucose rise, nucleotides and metabolites are generated by mitochondria and participate, together with cytosolic Ca2+, in the stimulation of insulin exocytosis. This review describes the mitochondria-dependent… CONTINUE READING

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