Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti‐cancer therapy?

@article{Goto2012NovelRO,
  title={Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti‐cancer therapy?},
  author={Hidemasa Goto and Ichiro Izawa and Ping Li and Masaki Inagaki},
  journal={Cancer Science},
  year={2012},
  volume={103}
}
DNA‐damaging strategies, such as radiotherapy and the majority of chemotherapeutic therapies, are the most frequently used non‐surgical anti‐cancer therapies for human cancers. These therapies activate DNA damage/replication checkpoints, which induce cell‐cycle arrest to provide the time needed to repair DNA damage. Due to genetic defect(s) in the ATM (ataxia‐telangiectasia mutated)‐Chk2‐p53 pathway, an ATR (ATM‐ and Rad3‐related)‐Chk1‐Cdc25 route is the sole checkpoint pathway in a majority of… 
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