Novel regulation by Rac1 of glucose- and forskolin-induced insulin secretion in INS-1 beta-cells.

@article{Li2004NovelRB,
  title={Novel regulation by Rac1 of glucose- and forskolin-induced insulin secretion in INS-1 beta-cells.},
  author={Jingsong Li and Ruihua Luo and Anjaneyulu Kowluru and Guodong Li},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2004},
  volume={286 5},
  pages={E818-27}
}
Stimulation of insulin secretion by glucose and other secretagogues from pancreatic islet beta-cells is mediated by multiple signaling pathways. Rac1 is a member of Rho family GTPases regulating cytoskeletal organization, and recent evidence also implicates Rac1 in exocytotic processes. Herein, we report that exposure of insulin-secreting (INS) cells to stimulatory glucose concentrations caused translocation of Rac1 from cytosol to the membrane fraction (including the plasmalemma), an… CONTINUE READING

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