Novel reaction systems for the synthesis of O-glucosides by enzymatic reverse hydrolysis

@article{Balogh2004NovelRS,
  title={Novel reaction systems for the synthesis of O-glucosides by enzymatic reverse hydrolysis},
  author={T. Balogh and L. Boross and J. Kos{\'a}ry},
  journal={Tetrahedron},
  year={2004},
  volume={60},
  pages={679-682}
}
Abstract Our studies are presented to replace alcohols as solvents in reverse hydrolytic reactions catalyzed by immobilized β-glucosidase to synthesize O -substituted β- d -glucopyranosides in preparative-scale. We found that 1,2-diacetoxyethane is a suitable solvent and O -alkyl or aryl β- d -glucosides were synthesized in moderate yields (after isolation 12–19%). In these reactions proportion of glucose and glucosyl acceptor hydroxy compounds was 1:20. We suggest that 1,2-diacetoxyethane can… Expand
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