Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors

@article{Varadi2012NovelRP,
  title={Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors},
  author={Karl Varadi and Stefan Michelfelder and Thomas Korff and Michael H. L. Hecker and Martin Trepel and Hugo A. Katus and J{\"u}rgen A. Kleinschmidt and Oliver J M{\"u}ller},
  journal={Gene Therapy},
  year={2012},
  volume={19},
  pages={800-809}
}
We have demonstrated the potential of random peptide libraries displayed on adeno-associated virus (AAV)2 to select for AAV2 vectors with improved efficiency for cell type-directed gene transfer. AAV9, however, may have advantages over AAV2 because of a lower prevalence of neutralizing antibodies in humans and more efficient gene transfer in vivo. Here we provide evidence that random peptide libraries can be displayed on AAV9 and can be utilized to select for AAV9 capsids redirected to the cell… CONTINUE READING
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