Novel rabies virus-neutralizing epitope recognized by human monoclonal antibody: fine mapping and escape mutant analysis.

@article{Marissen2005NovelRV,
  title={Novel rabies virus-neutralizing epitope recognized by human monoclonal antibody: fine mapping and escape mutant analysis.},
  author={Wilfred E. Marissen and Robert Arjen Kramer and Amy B. Rice and William C. Weldon and Michael Niezgoda and Milosz Faber and J. W. Slootstra and R. H. Meloen and Marieke Clijsters-van der Horst and Therese J. Visser and Mandy A C Jongeneelen and Sandra Thijsse and Mark Throsby and John de Kruif and Charles E. Rupprecht and Bernhard Dietzschold and Jaap Goudsmit and Alexander B H Bakker},
  journal={Journal of virology},
  year={2005},
  volume={79 8},
  pages={
          4672-8
        }
}
Anti-rabies virus immunoglobulin combined with rabies vaccine protects humans from lethal rabies infections. For cost and safety reasons, replacement of the human or equine polyclonal immunoglobulin is advocated, and the use of rabies virus-specific monoclonal antibodies (MAbs) is recommended. We produced two previously described potent rabies virus-neutralizing human MAbs, CR57 and CRJB, in human PER.C6 cells. The two MAbs competed for binding to rabies virus glycoprotein. Using CR57 and a set… CONTINUE READING

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