Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence.

@article{Chen2007NovelPM,
  title={Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence.},
  author={Wei Chen and Shuying Yang and Yoke Abe and Ming Li and Yucheng Wang and Jian-zhong Shao and En Li and Yi-Ping Li},
  journal={Human molecular genetics},
  year={2007},
  volume={16 4},
  pages={410-23}
}
Pycnodysostosis is a genetic bone disease featuring the unique bone homeostasis disorders of osteolysis and osteopetrosis in the same organism. The pathomechanism for pycnodysostosis has been largely unknown due to the unavailability of a pycnodysostosis mouse model with all the traits of the disease. We generated cathepsin K(-/-) mouse strains in the 129/Sv and C57BL/6J backgrounds and found that, only in the 129/Sv background, cathepsin K(-/-) mice exhibit many characteristics of the human… CONTINUE READING
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