Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus

@article{Wittbrodt1989NovelPR,
  title={Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus},
  author={Joachim Wittbrodt and Dieter Adam and Barbara Malitschek and Winfried M{\"a}ueler and Friedrich Raulf and Agnes Telling and S. R. M. Robertson and Manfred Schartl},
  journal={Nature},
  year={1989},
  volume={341},
  pages={415-421}
}
Malignant melanoma in Xiphophorus fish hybrids is caused by the activity of a dominant oncogene Tu. By combining genetic and molecular approaches, we have isolated the melanoma oncogene. We show that its level of expression correlates with the degree of malignancy of the tumour. The corresponding proto-oncogene is developmentally regulated. The Tu gene… CONTINUE READING