Novel proteomic tools reveal essential roles of SRP and importance of proper membrane protein biogenesis.

@article{Zhang2012NovelPT,
  title={Novel proteomic tools reveal essential roles of SRP and importance of proper membrane protein biogenesis.},
  author={Dawei Zhang and Michael J Sweredoski and Robert Leslie James Graham and Sonja Hess and Shu-Ou Shan},
  journal={Molecular & cellular proteomics : MCP},
  year={2012},
  volume={11 2},
  pages={
          M111.011585
        }
}
The signal recognition particle (SRP), which mediates cotranslational protein targeting to cellular membranes, is universally conserved and essential for bacterial and mammalian cells. However, the current understanding of the role of SRP in cell physiology and pathology is still poor, and the reasons behind its essential role in cell survival remain unclear. Here, we systematically analyzed the consequences of SRP loss in E. coli using time-resolved quantitative proteomic analyses. A series of… CONTINUE READING

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