Novel protein isoforms of the APC tumor suppressor in neural tissue

@article{Pyles1998NovelPI,
  title={Novel protein isoforms of the APC tumor suppressor in neural tissue},
  author={Richard B Pyles and Irma M. Santoro and Joanna Groden and Linda M. Parysek},
  journal={Oncogene},
  year={1998},
  volume={16},
  pages={77-82}
}
The conventional protein isoform of the APC tumor suppressor is 310 kD and is encoded by exons 1 – 15 of the APC gene. Other RNAs are expressed from the APC gene and include one form that contains an exon upstream of exon 1, designated BS, but this transcript does not include exon 1. This transcript recently has been shown to be enriched in non-dividing, terminally-differentiated cells (Santoro and Groden, 1997). To determine if the BS-containing transcript encoded an alternate APC protein… CONTINUE READING