Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neurons

@article{Rakotomamonjy2011NovelPE,
  title={Novel protective effect of mifepristone on detrimental GABAA receptor activity to immature Purkinje neurons},
  author={Jennifer Rakotomamonjy and C. Levenes and E. Baulieu and M. Schumacher and A. Ghoumari},
  journal={The FASEB Journal},
  year={2011},
  volume={25},
  pages={3999 - 4010}
}
  • Jennifer Rakotomamonjy, C. Levenes, +2 authors A. Ghoumari
  • Published 2011
  • Medicine, Biology
  • The FASEB Journal
  • Immature Purkinje neurons are particularly vulnerable cells. They survive in cerebellar slice cultures under treatment by the synthetic steroid mifepristone (RU486) that depolarizes them at this age. The present study aims at understanding the mechanism underlying this neuroprotective effect. In the developing cerebellum, the role of γ‐aminobutyric acid (GABA) in neuron survival is unknown. In 3‐d‐old mouse cerebellar slice cultures, we show that GABAA receptor activation is depolarizing and… CONTINUE READING
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