Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues.

@article{Takadate2013NovelPP,
  title={Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues.},
  author={Tatsuyuki Takadate and Tohru Onogawa and Tetsuya Fukuda and Fuyuhiko Motoi and Takashi Suzuki and Kiyonaga Fujii and Makoto Kihara and Sayaka Mikami and Yasuhiko Bando and Shimpei Maeda and Kazuyuki Ishida and Takashi Minowa and Nobutaka Hanagata and Hideo Ohtsuka and Yu Katayose and Shinichi Egawa and Toshihide Nishimura and Michiaki Unno},
  journal={International journal of cancer},
  year={2013},
  volume={132 6},
  pages={1368-82}
}
Pancreatic cancer is among the most lethal malignancies worldwide. We aimed to identify novel prognostic markers by applying mass spectrometry (MS)-based proteomic analysis to formalin-fixed paraffin-embedded (FFPE) tissues. Resectable, node positive pancreatic ductal adenocarcinoma (PDAC) with poor (n = 4) and better (n = 4) outcomes, based on survival duration, with essentially the same clinicopathological backgrounds, and noncancerous pancreatic ducts (n = 5) were analyzed. Cancerous and… CONTINUE READING