Novel procedures for derivatization of ribosomes for crystallographic studies.

Abstract

Undecagold and tetrairidium clusters have been used for the preparation of heavy-metal derivatives of ribosomal particles, necessary for the evaluation of phases in the x-ray structure determination of these large particles. To obtain specific binding, monofunctional reagents of the clusters were prepared and were covalently bound to free sulfhydryl groups… (More)

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@article{Weinstein1989NovelPF, title={Novel procedures for derivatization of ribosomes for crystallographic studies.}, author={S. D. DrellFM. Weinstein and W. Jahn and H. Hansen and Hilko Wittmann and Ada Etil Yonath}, journal={The Journal of biological chemistry}, year={1989}, volume={264 32}, pages={19138-42} }