Novel preparation of zein microspheres conjugated with PS-K available for cancer immunotherapy.

  title={Novel preparation of zein microspheres conjugated with PS-K available for cancer immunotherapy.},
  author={Y. Matsuda and T. Suzuki and E. Sato and M. Sato and S. Koizumi and K. Unno and T. Kato and K. Nakai},
  journal={Chemical & pharmaceutical bulletin},
  volume={37 3},
  • Y. Matsuda, T. Suzuki, +5 authors K. Nakai
  • Published 1989
  • Chemistry, Medicine
  • Chemical & pharmaceutical bulletin
  • Microspheres which entrapped PS-K were prepared using Zein as a carrier matrix by a one-step or two-step process in dimethyl sulfoxide-H2O media. Microspheres prepared by the latter process provided satisfactory recovery and uptake of PS-K. Use of a catalytic amount of dl-camphorsulfonic acid, glutaraldehyde and rapid addition of aqueous solution of polyvinylpyrrolidone into the reaction media are crucial for the preparation of fine and mono-dispersed microspheres. The release rate of PS-K… CONTINUE READING
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