Novel preparation of zein microspheres conjugated with PS-K available for cancer immunotherapy.

@article{Matsuda1989NovelPO,
  title={Novel preparation of zein microspheres conjugated with PS-K available for cancer immunotherapy.},
  author={Yoshiki Matsuda and Toshie Suzuki and Elichi Sato and Masayuki Sato and Sadayuki Koizumi and Kazutoshi Unno and Tomoki Kato and Kazuyuki Nakai},
  journal={Chemical & pharmaceutical bulletin},
  year={1989},
  volume={37 3},
  pages={
          757-9
        }
}
Microspheres which entrapped PS-K were prepared using Zein as a carrier matrix by a one-step or two-step process in dimethyl sulfoxide-H2O media. Microspheres prepared by the latter process provided satisfactory recovery and uptake of PS-K. Use of a catalytic amount of dl-camphorsulfonic acid, glutaraldehyde and rapid addition of aqueous solution of polyvinylpyrrolidone into the reaction media are crucial for the preparation of fine and mono-dispersed microspheres. The release rate of PS-K… CONTINUE READING