Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons.

@article{Zheng2005NovelPN,
  title={Novel potential neuroprotective agents with both iron chelating and amino acid-based derivatives targeting central nervous system neurons.},
  author={Hailin Zheng and Moussa B. H. Youdim and Louis M. Weiner and Mati Fridkin},
  journal={Biochemical pharmacology},
  year={2005},
  volume={70 11},
  pages={
          1642-52
        }
}
Antioxidants and iron chelating molecules are known as neuroprotective agents in animal models of neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson's disease (PD). In this study, we designed and synthesized a novel bifunctional molecule (M10) with radical scavenging and iron chelating ability on an amino acid carrier likely to be a substrate for system L, thus targeting the compound to the central nervous system (CNS). M10 had a moderate iron affinity in HEPES buffer… CONTINUE READING
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