Novel potassium channel blocker, 4-AP-3-MeOH, inhibits fast potassium channels and restores axonal conduction in injured guinea pig spinal cord white matter.

@article{Sun2010NovelPC,
  title={Novel potassium channel blocker, 4-AP-3-MeOH, inhibits fast potassium channels and restores axonal conduction in injured guinea pig spinal cord white matter.},
  author={Wenjing Sun and Daniel Smith and Yan Fu and Ji Xin Cheng and Steven Bryn and Richard Ben Borgens and Riyi Shi},
  journal={Journal of neurophysiology},
  year={2010},
  volume={103 1},
  pages={469-78}
}
We have demonstrated that 4-aminopyridine-3-methanol (4-AP-3-MeOH), a 4-aminopyridine derivative, significantly restores axonal conduction in stretched spinal cord white-matter strips and shows no preference in restoring large and small axons. This compound is 10 times more potent when compared with 4-AP and other derivatives in restoring axonal conduction… CONTINUE READING