Novel poly(ethylene glycol) derivatives for preparation of ribosome-inactivating protein conjugates.

Abstract

This study describes the synthesis, characterization, and reactivity of new methoxypoly(ethylene glycol) (mPEG) derivatives containing a thioimidoester reactive group. These activated polymers are able to react with the lysyl epsilon-amino groups of suitable proteins, generating an amidinated linkage and thereby preserving the protein's positive charge… (More)

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@article{Arpicco2002NovelPG, title={Novel poly(ethylene glycol) derivatives for preparation of ribosome-inactivating protein conjugates.}, author={Silvia Arpicco and Franco Dosio and Andrea Bolognesi and Chiara Lubelli and Paola Brusa and Barbara Stella and Maurizio Ceruti and Luigi Cattel}, journal={Bioconjugate chemistry}, year={2002}, volume={13 4}, pages={757-65} }