Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species.

@article{Silva2016NovelPM,
  title={Novel point mutations in the ERG11 gene in clinical isolates of azole resistant Candida species.},
  author={Danielly Beraldo dos Santos Silva and Luana Mireli Carbonera Rodrigues and Adriana Ara{\'u}jo de Almeida and Kelly M P Oliveira and Alex{\'e}ia Barufatti Grisolia},
  journal={Memorias do Instituto Oswaldo Cruz},
  year={2016},
  volume={111 3},
  pages={
          192-9
        }
}
The azoles are the class of medications most commonly used to fight infections caused by Candida sp. Typically, resistance can be attributed to mutations in ERG11 gene (CYP51) which encodes the cytochrome P450 14α-demethylase, the primary target for the activity of azoles. The objective of this study was to identify mutations in the coding region of theERG11 gene in clinical isolates of Candida species known to be resistant to azoles. We identified three new synonymous mutations in the ERG11… CONTINUE READING
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