Novel platelet activation receptor CLEC-2: from discovery to prospects.

@article{SuzukiInoue2011NovelPA,
  title={Novel platelet activation receptor CLEC-2: from discovery to prospects.},
  author={Katsue Suzuki-Inoue and Osamu Inoue and Yukio Ozaki},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2011},
  volume={9 Suppl 1},
  pages={44-55}
}
C-type lectin-like receptor 2 (CLEC-2) has been identified as a receptor for the platelet activating snake venom rhodocytin. CLEC-2 elicits powerful platelet activation signals in conjunction with Src, Syk kinases, and phospholipase Cγ2, similar to the collagen receptor glycoprotein (GP) VI/FcRγ-chain complex. In contrast to GPVI/FcRγ, which initiates platelet activation through the tandem YxxL motif immunoreceptor tyrosine-based activation motif (ITAM), CLEC-2 signals via the single YxxL motif… CONTINUE READING
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