Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling in salivary gland cells.

@article{Hasegawa2011NovelPO,
  title={Novel phosphorylation of aquaporin-5 at its threonine 259 through cAMP signaling in salivary gland cells.},
  author={Takahiro Hasegawa and Ahmad Azlina and Purevjav Javkhlan and Chenjuan Yao and Tetsuya Akamatsu and Kazuo Hosoi},
  journal={American journal of physiology. Cell physiology},
  year={2011},
  volume={301 3},
  pages={C667-78}
}
Aquaporin-5 (AQP5), a water channel, plays key roles in salivary secretion. The novel phosphorylation of AQP5 was investigated by using human salivary gland (HSG) cells and mouse salivary glands. In the HSG cells stably transfected with a wild-type mouse AQP5 construct, a protein band immunoreactive with antibody against phosphorylated PKA substrate was detected in the AQP5 immunoprecipitated sample, and its intensity was enhanced by short-term treatment of the cells with 8-bromo-cAMP… CONTINUE READING
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