Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases.

@article{Kotoris1998NovelPM,
  title={Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases.},
  author={Christopher C. Kotoris and M. J. Chen and S D Taylor},
  journal={Bioorganic \& medicinal chemistry letters},
  year={1998},
  volume={8 22},
  pages={
          3275-80
        }
}
Benzylic alpha,alpha-difluorosulfonates, alpha,alpha-difluorotetrazoles, and alpha,alpha-difluorocarboxylates of type 5 and 6 were synthesized and examined as potential phosphate biosteres for PTP1B inhibition. The alpha,alpha-difluorosulfonates and alpha,alpha-difluorotetrazoles were found to be more effective inhibitors than the analogous compounds bearing the fluoromalonyl group, a phosphate biostere currently being used for PTP inhibition. 
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