Novel pharmacotherapies to abrogate postinfarction ventricular remodeling

  title={Novel pharmacotherapies to abrogate postinfarction ventricular remodeling},
  author={Gerald W. Dorn},
  journal={Nature Reviews Cardiology},
Ventricular remodeling after myocardial infarction is defined as progressive chamber dilation and wall thinning, which leads to functional compromise. Remodeling is mediated by active processes of inflammation, fibrosis, and cardiomyocyte dropout over the weeks and months after infarction, and, therefore, provides a large temporal therapeutic window. In experimental models, interruption of molecular and physiological pathways that contribute to cardiomyocyte loss, and the resulting unfavorable… CONTINUE READING


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