Novel pharmacotherapies to abrogate postinfarction ventricular remodeling

@article{Dorn2009NovelPT,
  title={Novel pharmacotherapies to abrogate postinfarction ventricular remodeling},
  author={Gerald W. Dorn},
  journal={Nature Reviews Cardiology},
  year={2009},
  volume={6},
  pages={283-291}
}
Ventricular remodeling after myocardial infarction is defined as progressive chamber dilation and wall thinning, which leads to functional compromise. Remodeling is mediated by active processes of inflammation, fibrosis, and cardiomyocyte dropout over the weeks and months after infarction, and, therefore, provides a large temporal therapeutic window. In experimental models, interruption of molecular and physiological pathways that contribute to cardiomyocyte loss, and the resulting unfavorable… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 92 references

ePO administration on myocardial infarct size in patients with non-sTe acute coronary syndromes; results from a pilot study

  • A Liem
  • Int. J. Cardiol. 131,
  • 2009

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure

  • raake, P. w
  • Circ. Res
  • 2008

Similar Papers

Loading similar papers…