Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system.

  title={Novel perspectives for progesterone in hormone replacement therapy, with special reference to the nervous system.},
  author={Michael Schumacher and Rachida Guennoun and Abdel M Ghoumari and Charbel Massaad and Françoise Robert and Martine El-Etr and Yvette Akwa and Krzysztof M. Rajkowski and Etienne Emile Baulieu},
  journal={Endocrine reviews},
  volume={28 4},
The utility and safety of postmenopausal hormone replacement therapy has recently been put into question by large clinical trials. Their outcome has been extensively commented upon, but discussions have mainly been limited to the effects of estrogens. In fact, progestagens are generally only considered with respect to their usefulness in preventing estrogen stimulation of uterine hyperplasia and malignancy. In addition, various risks have been attributed to progestagens and their omission from… CONTINUE READING

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