Novel peptide toxins from acrorhagi, aggressive organs of the sea anemone Actinia equina.

@article{Honma2005NovelPT,
  title={Novel peptide toxins from acrorhagi, aggressive organs of the sea anemone Actinia equina.},
  author={Tomohiro Honma and Sonomi Minagawa and Hiroshi Nagai and Masami Ishida and Yuji Nagashima and Kazuo Shiomi},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={46 7},
  pages={768-74}
}
Two peptide toxins, acrorhagin I (50 residues) and II (44 residues), were isolated from special aggressive organs (acrorhagi) of the sea anemone Actinia equina by gel filtration on Sephadex G-50 and reverse-phase HPLC on TSKgel ODS-120T. The LD50 against crabs of acrorhagin I and II were estimated to be 520 and 80 microg/kg, respectively. 3'- and 5'-RACE established the amino acid sequences of the acrorhagin precursors. The precursor of acrorhagin I is composed of both signal and mature… CONTINUE READING

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