Novel peptide-based vaccines efficiently prime murine "help"-independent CD8+ T cell responses in the liver.

@article{Dikopoulos2004NovelPV,
  title={Novel peptide-based vaccines efficiently prime murine "help"-independent CD8+ T cell responses in the liver.},
  author={Nektarios Dikopoulos and Petra Riedl and R. Schirmbeck and J. Reimann},
  journal={Hepatology},
  year={2004},
  volume={40 2},
  pages={
          300-9
        }
}
Vaccines for the prophylactic and/or therapeutic immunization against hepatotropic pathogens (e.g., hepatitis B and hepatitis C virus) should establish long-lasting, specific antiviral effector/memory CD8+ T cell immunity in the liver. We describe a novel peptide-based vaccine in which antigenic major histocompatibility complex Class I-binding peptides are fused to a cationic (e.g., human immunodeficiency virus tat-derived) domain and complexed to immune-stimulating oligonucleotides. This… CONTINUE READING